Chronic Diseases Prevention Review

Investigate the clinical characteristics of advanced renal cell carcinoma associated with von Hippel-Lindau syndrome to improve the clinicians' understanding and reduce the incidence of missed diagnosis and misdiagnosis. Retrospective analysis of clinical data of 1 patient which suffered VHL syndrome complicated with advanced renal cell carcinoma in urology of Yantai Yuhuangding Hospital Affiliated to Qingdao University, review with the literature. Results: This case of patients without renal mass family history, which multiple mass were found in the pancreas and kidney, several Suspicious mass Scattered in Bilateral kidney, one of the mass located in left renal was performed biopsy under the guidance of ultrasound, and the Histological analysis confirmed after operation were left renal clear cell carcinoma. Surgical is obviously not suitable for treatment due to the number of the tumer. Therefore sunitinib has been used as molecular targeted drug to treatment in 2 years, and regular Computed tomography (CT) scan found the tumor was significantly reduced in follow-up period. VHL syndrome can occur in multiple systems, renal cell carcinoma is a common cause of late death, accurate clinical diagnosis and treatment, can improve the late survival rate of patients with VHL syndrome.